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Despite its advantages, methadone use is complicated due to high interindividual variability in pharmacokinetics. Numerous rotation practices off their opioids were suggested in mostly Caucasian communities. TARGETS This study is designed to describe our knowledge about opioid rotation to methadone for management of disease pain in a predominantly Asian population. METHODS A retrospective breakdown of 52 inpatients initiated on methadone for cancer tumors pain from June 2015 to Summer 2018 had been