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The remaining 2% of cases showed four roots with four canals (Variant IV) which were statistically significant. We concluded that within the constraints of our study, there was a difference in the root canal configuration of primary maxillary second molars in the investigated group of the Indian population. Krishnamurthy NH, Jose S, Thimmegowda U, Evaluation of Anatomical Variations in Root and Canal Morphology of Primary Maxillary Second Molars A Cone-beam Computed Tomography Study. Int J Clin Pediatr Dent 2021;14(5)628-632. Krishnam