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Thus, the kinase genes specifically expressed in intestinal and diffuse type gastric tumors and the kinase inhibitors to target Wnt signaling pathway in gastric cancer subtypes have been identified.We read with great interest the impressive multicentric study by Lamarca et al (1), concerning prognostic implications of multiple intrahepatic cholangiocarcinoma. We found however one very important methodological aspect that we think deserves further discussion, considering the authors' proposal of a revised staging system for this malignanc