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Ectopic expression of Gas7 restored mitochondrial morphology and distribution, as well as PINK1 expression in Gas7-null cortical neurons. Collectively, our results introduce a novel role of mouse Gas7 in determining the dynamics, morphology, and intracellular distribution of neuronal mitochondria, which are expected to be required for normal neuronal function. © 2020 The Authors.Human spaceflight endeavors present an opportunity to expand our presence beyond Earth. To this end, it is crucial to understand and diagnose effects of long-term