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Furthermore, the antitumor effects depended on the tumor progression stage in the SLN, the injection rate, and the volumes of administered drugs. We anticipate these optimal ranges to be a starting point for developing more effective drug regimens to treat metastatic LN with the LDDS.Forest and savanna ecosystems naturally exist as alternative stable states. The maximum capacity of these ecosystems to absorb perturbations without transitioning to the other alternative stable state is referred to as 'resilience'. Previous studies