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registered at the German Clinical Trial Register (DRKS) DRKS00023457 (05.11.202. The KMU-GO trial is registered at the German Clinical Trial Register (DRKS) DRKS00023457 (05.11.202. Alpha-fetoprotein-negative hepatocellular carcinoma (AFP-NHCC) ( 8.78 ng/mL) have special clinicopathologic characteristics and prognosis. The aim of this study was to apply a new method to establish and validate a new model for predicting the prognosis of patients with AFP-NHCC. A total of 410 AFP-negative patients with clinical diagnosed with HCC fo