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No or other nanophthalmos-associated gene variants were detected in the 12 normal controls. An appropriate approach was adopted to investigate the genetics of PACG through nanophthalmos-associated genes. A genetic variant, , was identified in four out of 45 PACG patients, which might be a novel candidate gene for PACG. An appropriate approach was adopted to investigate the genetics of PACG through nanophthalmos-associated genes. A genetic variant, MYRF, was identified in four out of 45 PACG patients, which might be a novel candidate gene