https://www.selleckchem.com/btk.html
We explored the functions and mechanisms of N-myc downstream-regulated gene 4 (NDRG4) in an amyloid beta 1-40 induced Alzheimer's disease cell model. The levels of total and phosphorylated Tau protein were significantly up-regulated and cell activity was decreased with increasing Aβ1-40 treatment in SH-SY5Y cells. The expression of NDRG4 mRNA and protein levels were significantly decreased that induced by Aβ1-40 in these cells. NDRG4 overexpression significantly alleviated Aβ1-40-induced SH-SY5Y apoptosis rates and caspases-3/7 activities. Equally,
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