What Causes Trucking Accidents? Trucks account for a small percentage of vehicles on the road, but they are a risk and can cause severe injuries or even death. Accidents involving large vehicles can result when drivers are distracted or fail to pay attention to their blind areas. Accidents in the trucking industry can also be caused by fatigued drivers. They work all day long, with no breaks in order to meet their limits. Driver Error Trucking accidents are caused by driver error which is a major problem. can be caused by a variety of causes.