https://www.selleckchem.com/pr....oducts/vps34-inhibit
The detected gene expression changes suggest that oxidative stress and/or inflammation pathways are likely implicated in the induction of (oxidative) DNA damage. Overall, all tested aSiO2 NM were not associated with marked in vivo toxicity following instillation or STIS. The genotoxicity findings for SiO2_7 from instillation and STIS are concordant; however, changes in STIS animals were more permanent/difficult to revert.Prolonged hyperinsulinemic hypoglycemia in infancy can result in developmental sequelae. A mutation in the
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