https://www.selleckchem.com/products/apd334.html
Genetic NOP receptor deletion resulted in decreased nicotine intake, decreased motivation to self-administer and attenuation of cue-induced nicotine reinstatement. LY2817412 reduced nicotine intake in NOP but not in NOP rats, confirming that its effect is mediated by inhibition of NOP transmission. Finally, injection of LY2817412 into the VTA but not into the NAc or CeA decreased nicotine self-administration. These findings indicate that inhibition of NOP transmission attenuates the motivation for nicotine through mechanisms involving th
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