https://www.selleckchem.com/pr....oducts/iwr-1-endo.ht
Overall, this study outlines an important role for the GET complex in ER targeting of non-imported mitochondrial carrier proteins. To investigate whether CEACAM7 represents a novel therapeutic target for treating pancreatic ductal adenocarcinoma (PDAC) and to generate CEACAM7-targeting CAR T cells to test this hypothesis. We identified CEACAM7 (CGM2), a member of the CEA family of proteins with expression restricted to the colon and pancreas, as a potential CAR T-cell target for PDAC. We probed a panel of PDAC tumor sections as well
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