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Thus, it is imperative to develop renewable islets for diabetes research and treatment. Up to now, considerable efforts have been made to derive insulin-secreting cells from real human pluripotent stem cells with significant success. However, the in vitro generation of functional islet organoids remains a challenge due to some extent to our poor understanding of the signaling particles essential for managing differentiation pathways to the self-assembly of practical islets from stem cells. Be
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