https://www.selleckchem.com/pr....oducts/ldc195943-imt
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammatory responses and fibrosis. Our previous studies provided evidence that group IVA phospholipase A (IVA-PLA ), a key PLA isozyme in the arachidonic acid cascade, is involved in the development of NASH. However, which types of cells are critical for the IVA-PLA -dependent onset and progression of NASH is unclear. We elucidated the effects of the cell-type-specific deficiency of IVA-PLA in mice on the development of NASH. Cell-type-specific IVA-PLA -conditi
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