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This study aimed to investigate the effects of Rosa damascena Mill. essential oil on the vascular activity of rat thoracic aorta and its underlying mechanisms. Experiments were performed using the isolated tissue bath model and Wistar rats. 0.1, 1, 10, and 100µg/mL concentrations of rose oil were administered in all groups. To determine the vasoactive effects of rose oil, submaximal contractions were conducted by applying 10 M PE and 45mM KCl separately in both endothelium-intact and -denuded segments. Time-matched distilled water group
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