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05) was observed. In the SMILE cohort, no significant change in CD relative to baseline was observed. However, at 5 years postoperatively, in both groups, a significant decrease in CD was observed in three zones of three layers (all P less then 0.001). The change in CD was similar between groups at postoperative 6-12 months, but at 5 years the magnitude of change was significantly smaller in SMILE than FS-LASIK in the anterior and central layers (all P less then 0.05). Conclusion CD with the Scheimpflug imaging system showed a significan