https://www.selleckchem.com/pr....oducts/c-176-sting-i
respectively. These analyses were extended to include measured literature values for binding in human liver microsomes for a larger set of compounds (n=697). For the larger dataset of compounds, microsomal binding was well predicted for neutral compounds (r2=0.67 - 0.7 using the Poulin, Austin, or Turner-Simcyp methods but not for acidic or basic compounds (r2 less then 0.5) using any of the models. While the lipophilicity-based models can be used, the in vitro binding should be measured for compounds where more certaint
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