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The interaction between TP53 and BCAR1 plays an important role in enhancing cancer cell invasion. Thus, our study suggests a disruption of the TP53 -BCAR1 binding as a potential therapeutic approach for TP53 -harbouring cancer patients. The interaction between TP53R273H and BCAR1 plays an important role in enhancing cancer cell invasion. Thus, our study suggests a disruption of the TP53R273H-BCAR1 binding as a potential therapeutic approach for TP53R273H-harbouring cancer patients. Progesterone receptors (PR) are potent modifiers of endo