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Caveolae in melanocytes are modulated by ultraviolet radiations and keratinocytes-released factors, like miRNAs. Preventing caveolae formation in melanocytes increases melanin pigment synthesis through upregulation of cAMP signaling and reduces cellular protrusions, cell-cell associates, pigment transfer and epidermis coloration. Completely, we see that caveolae serve as molecular hubs that couple signaling outputs from keratinocytes to technical plasticity of pigment cells. The control of intercellular i