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Conclusion Findings provide additional evidence for the viability of the eight-step instructional model as a methodology to promote the communication skills of students who utilize AAC, and also point to the advanced practice and feedback element of the model as a potential mediator of intervention outcomes.Immunomodulation by adipose-tissue-derived stem cells (ADSCs) is of special interest for the alleviation of damaging inflammatory responses in central nervous system injuries. The present study explored the effects of cerebrospinal