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Hereditary heritability of PAU ended up being enriched in brain and in conserved and regulatory genomic regions. Mendelian randomization proposed causal effects on liability to PAU of compound usage, psychiatric condition, risk-taking behavior and intellectual overall performance. In conclusion, this large PAU meta-analysis identified book danger loci and revealed genetic interactions with many other traits.Prolonged obesity is related to cerebrovascular dysfunction; however, the underlying
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