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In addition, Overexpression of Aurora A kinase is involving medication weight and bad prognosis in lots of cancers including breast cancer. Consequently, Aurora A kinase has been considered as an appealing anticancer target for the treatment of peoples cancers. Herein, A series of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives had been created, synthesized, and assessed as Aurora A kinase inhibitors. The cell-based cytotoxicity assays showed that compound 16h was the absolute most pot