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CONCLUSIONS Liver injury brought on by FXR agonism in cholestasis is FXR-dependent and it is reversed by FXR and Mafg antagonism or Nrf2 induction. V.Omega-3 polyunsatuarted efas (PUFA) tend to be connected with hypolipidemic and anti inflammatory effects. Nevertheless, omega-3 PUFA, frequently administered as triacylglycerols or ethyl esters, could also compromise sugar metabolic rate, specifically in obese kind 2 diabetic patients. Phospholipids represent an altern