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In our research, we examined the part of sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) on OEC expansion. At first, reverse transcription-PCR (RT-PCR), western blot and immunostaining disclosed that S1PRs were very expressed into the OECs in vitro as well as in vivo. Moreover, we found that S1P treatment promoted the proliferation of main cultured OECs mediated by S1PR1. Mechanistically, yes-associated protein (YAP) had been nee