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Even though the team size did not allow a statistically relevant difference, we underline that just the helical group showed no iatrogenic radial lesion. This technique deserves further interest. STANDARD OF EVIDENCE Level 3, retrospective cohort study.BACKGROUND Consensus is lacking in connection with dose and timing of tranexamic acid (TXA). The goal of this study was to see whether multiple-dose intravenous TXA further decreased blood reduction and attenuated irritation after total knee arthropla