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Single-drop microextraction (SDME) techniques are efficient approaches to pretreatment of aqueous samples. The main advantage of SDME lies in the miniaturization of the solvent extraction process, minimizing the hazards associated with the use of toxic organic solvents. Thus, SDME techniques are cost-effective, and represent less harm to the environment, subscribing to green analytical chemistry principles. In practice, two main approaches can be used to perform SDME - direct immersion (DI)-SDME and headspace (HS)-SDME. Even though the DI