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2% vs. 38.5%, p = 0.02 and time from metastasis to start of capecitabine was longer (mean 3.5 vs. 2.7years, p = 0.02. ORR was 22%. Median TTP and OS were 28 and 58weeks, respectively. In multivariate analysis (only performed for TTP), ER positivity (hazard ratio (HR) = 0.529, p 0.0001), HER2 negativity (HR = 0.582, p = 0.024), absence of LN (HR = 0.751, p = 0.008) and liver involvement (HR = 0.746, p = 0.013), older age at capecitabine start (HR = 0.925, p 0.0001) and younger age at diagnosis of MBC (HR = 0.935, p = 0.001) w