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ELISA studies implicated cAMP and/or sphingosine-1-phosphate efflux in the mechanism by which these transporters mediate their effects. However, this needs to be investigated further, as it is key to understand the mechanisms before they can be considered as targets for treatment.Stick-slip friction of elastomers arises due to adhesion, high local strains, surface features, and viscous dissipation. In situ techniques connecting the real contact area to interfacial forces can reveal the contact evolution of a rough elastomer surface lead