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519, p 0.001) and creatinine level (r = 0.167,p = 0.034). The multivariate regression analysis found that the severity of proteinuria was independently correlated to MHR (p 0.001). According to the receiver operating characteristic curve analysis, the optimal cut-off level for MHR in NS was 10.08 (area under the curve of 0.704, sensitivity of 68%, and a specificity of 62%). Our study is the first to compare the severity of proteinuria and renal functions with MHR in patients with primary NS. We believe that MHR can be used a