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BACKGROUND Primordial odontogenic tumor (POT) is a novel entity that was described in 2014 and that is included in the group of benign mixed epithelial and mesenchymal odontogenic tumors.In recent years, several papers have added new cases with some clinical and histopathological aspects that slightly differ from those described in the original report.The aim of this systematic review is to update all available data on POT published in the literature and to identify those features of the neoplasm that require further investigation. MATERI