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Hence, it has the potential to monitor tumor activity, predict prognostic outcomes, and guide individualized therapies.PURPOSE OF REVIEW The aim of this review is to describe the major steps leading to the immunosuppressive tumor microenvironment and to summarize some of the new immunotherapies that interfere with these mechanisms. RECENT FINDINGS Immunotherapy has improved the outcome of relapsed/metastatic head and neck squamous cell carcinoma (HNSCC). However, most patients still do not respond to treatment and median overall surviva