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This study achieved maximum removal of ochratoxin A (OTA) during the grape juice clarification process with minimal reduction in antioxidant compounds (phenolic acid, flavonoids, and antioxidant capacity by FRAP) by the RSM method. Independent variables included three types of clarifiers-gelatin, bentonite, and diatomite (diatomaceous earth)-at a concentration level of 0.25-0.75% and clarification time of 1-3 h. OTA was measured by high-performance liquid chromatography with fluorescence detection. Clarifying agent concentration and clari