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The spatial circulation structure of [Ca2+]i among cells ended up being investigated by Moran's I, an index of spatial autocorrelation. We unearthed that 30 μM and 50 μM AHL caused opposing osteoblast fates. At 50 μM, AHL inhibited osteoblast differentiation by promoting mitochondrial-dependent apoptosis and negatively regulating osteogenic marker genes, including Runx2, Osterix, bone sialoprotein (Bsp), and osteocalcin (OCN). On the other hand, extended treatment with 30 μM AHL presented osteobl
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