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Histidine buffer at pH6.5 showed a lower ISP than pH5.7. This systematic study via orthogonal analyses demonstrated that subcutaneous ISP is significantly influenced by solution composition. This systematic study via orthogonal analyses demonstrated that subcutaneous ISP is significantly influenced by solution composition. Perihemorrhagic edema (PHE) growth has been gradually considered as predictor for outcome of Intracerebral hemorrhage (ICH) patients. The aim of our study was to investigate correlation between non-contrast computed to