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entification processes that support systematic review production. The objective of this study was to assess approaches to reduce immeasurable time bias in case-crossover (CCO), case-time-control (CTC), and case-case-time-control (CCTC) designs. We used Korea's health care database that has inpatient and outpatient prescriptions and an empirical example of benzodiazepines and mortality among the elderly. We defined our unbiased exposure setting using all prescriptions and a pseudo-outpatient setting using outpatient records only. In th
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