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e relative expression level of mRNA and protein of ACC1 (mRNA 0.89 ± 0.54, protein 0.28 ± 0.11) were also significantly lower than those in model group (mRNA 1.39 ± 0.19, protein 0.47 ± 0.24) (mRNA F = 3.948, P = 0.036, protein F = 10.933, P = 0.048). Conclusion 1.25(OH) (2)D(3) can reduce liver fat deposition in rats fed with MCD by inhibiting the expression of fat / CD36 and ACC1.Objective To investigate the correlation between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 and transmembrane 6 superfamily member 2 (TM