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e neurons reacted immediately after ammonia arrived the slice. We propose that a brief augmentation of neuronal activity by NH 4 + may occur either spontaneously during arousal or induced by inhalation of smelling salts.A high-fat diet (HFD) and loss of endogenous estrogens increases the risk for type 2 diabetes (T2D) and insulin resistance. Although exercise is known to prevent and manage insulin resistance, the cellular mechanisms remain largely unknown, especially in the context of a combined HFD and endogenous estrogen loss via ovar