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Copyright © 2020 Macêdo-Souza, Maisonnette, Filgueiras, Landeira-Fernandez and Krahe.Previous researches suggested that both maladaptive tension response and circadian dysregulation might have a job within the background of migraine. However, results of circadian genes on migraine have not been tested yet. In today's research, we investigated the main effectation of rs10462028 of the circadian locomotor output rounds kaput (CLOCK) gene and its particular interactio