https://www.selleckchem.com/pr....oducts/a-1210477.htm
CAT-DCs also displayed significantly increased NADPH-oxidase-driven H O -production, enhancing low-density lipoprotein (LDL)-uptake. Blocking LDL-uptake restored maturation, and attenuated the immunosuppressive properties of CAT-DCs. Here, we report a novel axis between H O - and LDL-metabolism controlling tolerogenic properties in moDCs. Given that moDCs are pivotal in tumor-rejection, and lipid-accumulation is associated with tumor-immune-escape, LDL-metabolism appears to play an important role in tumor-immunology. Here, we report a
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