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Breast cancer (BC) remains a public health dilemma in the world and it is one of the leading causes of death among women. Trastuzumab is a kind of commonly-used drugs in the treatment of BC, which especially can provide substantial benefits for HER2-positive BC. However, its long-time usage results in the emergence of resistance, which cuts down its efficacy in BC and leads to a poorer overall survival rate. Hence, the attempt of this study was to investigate how the drug resistance was enhanced. It has been identified that circHIPK3 co