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7% and was non-inferior to the current standard of fast frozen HE-stained sections (87.3 vs. 88.9%, p = 0.783). We found a substantial diagnostic correlation between SRH-based neuropathological diagnosis and HE-stained frozen sections (κ = 0.8). The interpretability of intraoperative SRH imaging was demonstrated to be equivalent to the current standard method of HE-stained frozen sections. Further research using this label-free innovative alternative vs. conventional staining is required to determine to which extent SRH-
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