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Background Infections are the second leading cause of death among patients undergoing hemodialysis. However, preventive measures against infectious diseases are limited and have not been made mandatory for patients. Objective To investigate the incidence of infectious diseases before and during the coronavirus disease (COVID-19) pandemic. Design A historical comparative study of a prospective cohort. Setting(s) February 1, 2015 to January 31, 2020 was defined as the period before the mitigative confrontation of the COVID-19 pandemic in Ch