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Accelerated warming was noticed during the last two decades with an increase in the probability of extreme events of temperatures (minimum, maximum, average) at the higher end. Precipitation was found to be more variable across the observed period and suggested no trend in the study area.Oral administration of indigo naturalis (IN) can induce remission in ulcerative colitis (UC); however, the underlying mechanism remains unknown. The main active components and targets of IN were obtained by searching three traditional Chinese medicine n