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The remarkable chemical and photophysical properties of 3nm diameter nanomaterials and their emergence as tools with widespread biomedical application presents significant opportunities to the cryo-microscopy community. In this review, we will outline developments in the synthesis, functionalisation and labelling uses of both AuNPs and AuNCs in cryo-ET, while discussing their potential as multi-modal probes for cryo-CLEM. During the treatment of diseases, histone deacetylases (HDAC) may have side effects such as strong immune inhibit