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Meanwhile, monocytes might have a potential role in affecting NSCLC immunotherapy and underlying mechanism has been explored. Finally, we found that SEC14L3 and APCDD1L were the underlying targets affecting immunotherapy, as well as patients survival. These results can provide direction and guidance for future research focused on NSCLC immunotherapy. These results can provide direction and guidance for future research focused on NSCLC immunotherapy.De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival, and a