https://asp2215inhibitor.com/e....valuation-about-the-
Knockdown of DR5 or overexpression of survivin inhibited combined treatment with IITZ-01 and TRAIL-induced apoptosis. IITZ-01 downregulated protein appearance of Cbl, ubiquitin E3 ligase, and decreased appearance standard of Cbl markedly led to increase DR5 necessary protein expression and TRAIL sensitivity. Furthermore, IITZ-01 decreased appearance amount of survivin protein via downregulation of deubiquitinase ubiquitin-specific protease 9X (USP9X) appearance. Taken together, th
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