https://www.selleckchem.com/pr....oducts/epacadostat-i
RNA-seq analysis identified TNF- and NF- B as potential targets of CX3CR1 inhibition. In KI-A-treated vessels compared with KI-V, there was decreased gene expression of , , and ; with reduction of , NF- B, and ; decreased M1, Ly6C, smooth muscle cells, fibroblast-activated protein, fibronectin, and proliferation; and increased TUNEL and M2 staining. In cell culture, monocytes stimulated with PMA and treated with hCX3CR1 VHH had decreased , , proliferation, and migration. CX3CR1 blockade reduces VNH/VS formation by decreas
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