https://www.selleckchem.com/pr....oducts/zebularine.ht
High tumor mutational burden (TM is associated with response to checkpoint blockade in several cancers. We identify pathogenic germline variants associated with increased TMB (GVITM. GVITMB were found in 7 genes using a pan-cancer approach (APC, FANCL, SLC25A13, ERCC3, MSH6, PMS2, and TP53) and 38 gene sets (e.g., those involved in DNA repair and programmed cell death). GVITMB were also associated with mutational signatures related to the dysfunction of the gene carrying the variant, somatic mutations that further affect the gene
Like
Comment
Share
