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001. Age and LVEF were not significantly associated with the uric acid increase over time (p=0.250 and p=0.327, respectively) but were statistically different according to gender (p=0.036). In heart failure with reduced ejection fraction (HFrEF), the uric acid level increases progressively towards the last periods before exitus. This increase is more pronounced in men. Key Words Heart failure, Serum uric acid levels, Prognosis, Gender. In heart failure with reduced ejection fraction (HFrEF), the uric acid level increases progressively t