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Primary biliary cholangitis (PBC) is an immune-mediated chronic cholestasis, in which T cell homeostasis plays an important role. Lysosomal-associated membrane protein 2 isoform A (LAMP-2A) has been implicated in the regulation of CD4 T cell responses. We comprehensively evaluated the immunobiology of CD4 T cells in patients with PBC (PBC, n=42), chronic hepatitis B (CHB, n=2, and healthy control subjects (HC, n=2 by flow cytometry including activation status and LAMP-2A expression. Additionally, we investigated the activation respon
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